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WebExpert opinion: TNFα antagonists may be more immunosuppressive than non-TNF-targeted biologic agents and increase the risk of systemic infections. Most consistent risk factors for serious infections include use of combination therapy with immunosuppressive agents and/or corticosteroids, moderate to severe disease activity, and older age. WebImmunosuppressive therapy may be required in some of the patients with autoimmune cytopenias: Mycophenolate mofetil as the first line for chronic treatment. Sirolimus … dusk to poets clue
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