WebFeb 27, 2007 · Spironolactone is a well-known cause of gynecomastia and may act by displacing androgen from the androgen receptor and sexual-hormone-binding globulin, and by causing increased metabolic clearance of testosterone and higher estradiol production. 1, 2 The patient's spironolactone was replaced with eplenerone, a new aldosterone … WebThis drug can induce gynecomastia after one month only of treatment, with a dose-dependent incidence. 3 Among the H2 histamine receptor blockers, cimetidine seems …
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