Lamp2a是什么

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August undefined, 2024

TīmeklisABSTRACT. LAMP1 (lysosomal-associated membrane protein 1) and LAMP2 are the most abundant protein components of lysosome membranes. Both LAMPs have common structures consisting of a large lumenal domain composed of two domains (N-domain and C-domain, which are membrane-distal and -proximal, respectively), both … TīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome.

SciAdv丨LAMP2A介导了蛋白质向外泌体的分选和包装 - 外泌体资 …

Tīmeklis2024. gada 25. marts · Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a process that is dependent on the membrane protein LAMP2A. Moreover, we demonstrate that this mechanism is independent of the ESCRT machinery but dependent on HSC70, … TīmeklisCMA is a selective autophagic process that depends on LAMP2A (lysosomal-associated membrane protein 2A), a mammal and bird-specific membrane glycoprotein that translocates cytosolic proteins containing a KFERQ-like peptide motif across the lysosomal membrane. checkers or rally\u0027s locations

Recombinant Anti-LAMP2A antibody [EPR4207(2)] - …

Tīmeklis2024. gada 1. maijs · The structure of LAMP2A comprises a large lumenal domain composed of two homologous subdomains (N-domain and C-domain, both with the β-prism fold), a transmembrane domain, and a short cytoplasmic tail. Although the homophilic interaction between LAMP2A molecules and the interaction between … Tīmeklis2024. gada 24. apr. · 这些作者表示，人们在一生中产生相同数量的lamp2a受体，不过，这些受体随着年龄的增加而退化得更快，因此老年人往往有较少的受体用于将不需要 ... TīmeklisLamp2a is released from the membrane by the action of these proteases, and then the truncated lamp2a is rapidly degraded within the lysosomal matrix. Membrane degradation of lamp2a is a regulated process that is inhibited in the presence of substrates for chaperone-mediated autophagy and under conditions that activate that … flashing 3080ti with 3090 bios

Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are ... - Hindawi

Tīmeklis2024. gada 18. marts · LAMP2 has three isoforms: LAMP2A, LAMP2B, and LAMP2C. LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer using a recombinant adeno-associated virus 9 carrying human LAMP2B (AAV9.LAMP2B) in a Lamp2 knockout (KO) mouse, … TīmeklisLAMP2. Lysosome-associated membrane protein 2 ( LAMP2 ), also known as CD107b ( C luster of D ifferentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins . The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides … flashing 3d printer firmwareTīmeklisCritically, Lamp2a is required for HCC xenograft growth in vivo by helping cells to avoid apoptosis and promoting cell proliferation. Furthermore, a significant correlation between Lamp2a expression and tumor size or cumulative recurrence was uncovered in HCC patients. Collectively, the present study shows that impaired Lamp2a expression in … checkers or rally\u0027s near me

"Tīmeklispamps通过识别一些保守的非自我分子，激活先天免疫反应，保护宿主免受感染。细菌脂多糖(lps)是革兰氏阴性菌细胞膜上的内毒素，被认为是pamps的原型类。 lps由tlr4特异性识别，tlr4是先天免疫系统的一种识别受体。其他pamps包括细菌鞭毛蛋白(tlr5识别)、革兰氏阳性细菌的脂磷壁酸(tlr2识别)、肽聚糖 ... " - Lamp2a是什么

Lamp2a是什么

LAMP2 lysosomal associated membrane protein 2 [ (human)]

Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and Homeostatic Agents. 16 (2): 147–51. PMID 12144129. • Schleutker J, Haataja L, Renlund M, Puhakka L, Viitala J, Peltonen L, … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly metastatic cancer such as colon cancer and melanoma. They are rarely found on … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an overview of all the structure information … Skatīt vairāk TīmeklisLAMP2 lysosomal associated membrane protein 2 [ (human)] Gene ID: 3920, updated on 7-Feb-2024 Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis.

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TīmeklisBackground: Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. Methods: Mouse tumor models and cancer patients' samples were … TīmeklisLAMP2A was immunoprecipitated from 1mg of HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysate with unpurified ab125068 at 1/100 dilution. Western blot was performed from the …

TīmeklisLAMP2A was immunoprecipitated from 1mg of RAW 264.7 (Mouse macrophage cells transformed with Abelson murine leukemia virus) whole cell lysate with ab125068 at 1/100 dilution. Western blot was performed from the immunoprecipitate using unpurified ab125068 at 1/2000 dilution. TīmeklisLAMP2蛋白；溶酶体关联膜蛋白2 (LAMP2)重组蛋白英文名称：Recombinant Lysosomal Associated Membrane Protein 2 (LAMP2) CD107-B; CD107b; LAMP-2C; LAMPB; LGP96; Lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B 来源：原核表达宿主：E.coli 规格：10μg 50μg 200μg 1mg 5mg 内毒素水 …

Tīmeklis2024. gada 23. jūn. · LAMP2基因9号外显子的剪切差异可致所编码的LAMP2蛋白存在LAMP2A、LAMP2B及LAMP2C 3种亚型，区别仅在于溶酶体羧基末端跨膜区域及胞浆短尾。 LAMP2A及LAMP2C在全身各组织中广泛表达，而LAMP2B则选择性地在心肌、骨骼肌及脑组织中高水平表达相关问答来来来，大神教你如何冻存细胞，里面窍门可 … Tīmeklis2024. gada 25. marts · LAMP2A originates from the alternative splicing of the LAMP2 gene, which contains nine exons, including three different splice variants of the exon 9 (A, B, and C) . All splice variants share a common luminal domain but contain distinct cytosolic and transmembrane regions.

Tīmeklis2024. gada 8. febr. · A Western blot analysis of LAMP2A and LAMP1 expression in Hep3B cells treated with 10 μM SP600125 for the indicated times.B Western blot analysis of LAMP2A expression in Hep3B cells treated for 6 ... flashing 3rd brake light legalTīmeklisAnti-LAMP2A antibody [EPR4207 (2)] - Lysosome Marker (ab125068) Research with confidence – consistent and reproducible results with every batch Long-term and scalable supply – powered by … checkers or rally\\u0027s near meTīmeklis2024. gada 23. jūn. · bamboopiggy. LAMP2基因9号外显子的剪切差异可致所编码的LAMP2蛋白存在LAMP2A、LAMP2B及LAMP2C 3种亚型，区别仅在于溶酶体羧基末端跨膜区域及胞浆短尾。. LAMP2A及LAMP2C在全身各组织中广泛表达，而LAMP2B则选择性地在心肌、骨骼肌及脑组织中高水平表达. flashing 3157 brake light bulbTīmeklis2024. gada 24. nov. · HEK293 cells were transfected with myc-LAMP2A (wt) or (mt, T211A and T213A) for 40 h, and proteins were collected for IP with anti-myc for p38 MAPK in vitro kinase assay (top left); and SN4741 ... flashing 3timesTīmeklisLAMP1：LAMP2 溶酶体相关膜蛋白1和2（LAMP1: LAMP2）是溶酶体膜的组成部分，因此构成了极佳的溶酶体标志物，以此来作为溶酶体的maker再合适不过。更多的免疫学相关知识，可以关注优宁维的“小优博士”，即可观看往期视频和本期讲座预告！发布于 2024-07-28 22:45 细胞器蛋白纯化细胞生物学 flashing 4x4Tīmeklis2024. gada 7. nov. · LAMP2A possesses a highly glycosylated luminal region that is common to all LAMP2 isoforms and a specific 11-amino-acid-long cytosolic C-terminal tail . By virtue of this particularity, LAMP2A (but neither of the 2 other isoforms, LAMP2B and LAMP2C), participates in CMA, which facilitates selective import and … flashing a3sTīmeklisAnti-LAMP2A antibody [EPR4207 (2)] - Lysosome Marker (ab125068) Research with confidence – consistent and reproducible results with … checkers o\\u0027reilly auto parts