Web14. nov 2012 · Sp1 regulates thousands of genes, such as those encoding vascular endothelial growth factor (VEGF), p21 CIP1/WAF1, 12 ( S )-lipoxygenase, phosphatase 2A (PP2A), and Sp1 itself. Thus, Sp1 is important for a variety of physiological processes, including angiogenesis, cell cycle progression, inflammation, and senescence [ 3 – 6 ]. WebSP1 sites are often located close to binding sites for activator proteins (AP-1/AP-2), Ets (E-twenty-six) family TFs, or nuclear factor 1 (NF1), and the coordinated activation or …
SP1 - What does SP1 stand for? The Free Dictionary
WebSpecificity protein 1 (Sp1) is a zinc finger family transcription factor. Sp1 can regulate a number of genes that influence cell survival and proliferation. Notably, Sp1 … Web11. apr 2014 · PML inhibits Sp1-mediated transcriptional activation of the epidermal growth factor receptor (EGFR) gene by interacting with and preventing Sp1 from binding to its promoter. Our current study is to further understand the mechanistic insight of how PML interacts with Sp1 and inhibits Sp1 functions in vivo. dropship directory
Sp1 and the
WebInterestingly, the function of SP3, a protein related to SP1 with similar DNA binding specificity, depends on the number of SP1 binding motifs in the promoter. SP3 works as an activator for promoters containing a single SP1 binding motif, but it represses transcription from promoters containing multiple SP1 binding motifs by inhibiting SP1 ... Web15. sep 2009 · Sp1 expression levels show a dramatic increase during transformation and this could play a critical role for tumour development or maintenance. Although Sp1 deregulation might be beneficial for tumour cells, its overexpression induces apoptosis of untransformed cells. Web8. jan 2015 · Sp1 both activates and suppresses the expression of a number of essential oncogenes and tumor suppressors, as well as genes involved in essential cellular … dropship directory usa